Tabla de contenido:

• Environmental health criteria for 2,4-dichlorophenoxyacetic acid
• Summary and recommendations for further studies
• Summary
• Recommendations for further studies
• Properties and analytical methods
• Physical and chemical properties of 2,4-d
• Determination of 2,4-d
• Sources of environmental pollution
• Production of 2,4-d herbicides
• Uses
• Disposal of waster
• Environmental transport, distribution, and transformation of 2,4-d
• Drift and volatization inthe atmosphere
• Movement within and from the soil
• Contamination of water
• Environmental transformation and degradation processes
• Bioconcentration
• Environmental levels and exposure
• Levels of 2,4-d residues in the environment
• Occupational exposure to 2,4-d during the production, handling, and use of chlorophenoxy herbicides
• Exposure of bystanders to 2,4-d
• Estimated exposure by the general population in 2,4-d-use areas
• Chemobiokinetics and metabolism
• Uptake via different routes of exposure
• Distribution and transformation in the body
• 2,4-d levels in body tissues and fluids
• Elimination and biological half-life
• Chlorinated dibenzo-p-dioxins CDDs
• Effects of 2,4-d on animals
• General introduction
• Acute effects
• Skin and eye irritancy
• Skin sensitization
• Lethal doses and concentrations LD50 and LC50
• Subchronic and chronic toxicity
• Fetotoxicity, teratogenicity, and reproductive effects
• Mutagenicity and related effects
• Carcinogenic effects on experimental animals
• Effects on man, clinical and epidemiological studies
• Acute poisoning and occupational overexposure
• Epidemiological studies of the chronic effects of 2,4-d
• Studies on mutagenic effects in workers exposed to 2,4-d
• Carcinogenic effects
• Treatment of poising in human beings
• Evaluation of health risks to man from exposure to 2,4-d
• General considerations
• Estimated intake of 2,4-d by the population in a 2,4-d-use area
• Safety factors
• Evaluation of health risks from 2,4-d exposure
• Recommendations on exposure